![]() This may seem weird, as a sodium channel blocker is supposed to act as a membrane stabiliser. In the brain, propanolol decreases the seizure threshold. It has nasty sodium channel blocking effects and it prolongs QRS duration moreover it penetrates the blood brain barrier. Most deaths from β-blocker overdose are associated with propanolol. ![]() However, a few stand out as being particularly toxic. This table is very similar to the one offered in Goldfranks' Manual of Toxicologic Emergencies.Įven though one cannot call any β-blocker overdose intrinsically "safe", many drugs are relatively benign. Pharmacological properties of commonly used β-blockers Additional resources should include the LITFL CCC entry, which is clear and concise. The cardinal differences in β-blocker and CCB toxicological syndromes are discussed at the very end of this chapter, which otherwise mainly deals with β-blockers on their own.
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